Yazar "Serhatlı, Müge" için listeleme
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Evaluation of apoptotic molecular pathways for smooth muscle cells isolated from thoracic aortic aneurysms in response to oxidized sterols
Adıgüzel, Zelal; Arda, Nazlı; Kaçar, Ömer; Serhatlı, Müge; Gezer Taş, Serpil; Baykal, Ahmet Tarık; Baysal, Kemal; Açılan, Ceyda (Springer, 2014)Oxysterols, oxygenated derivatives of cholesterol, are found abundantly in the plasma and atherosclerotic plaques, a common risk factor for thoracic aortic aneurysms (TAAs). Among the oxysterols, namely 7-ketocholesterol ... -
Identification of ApoA1, HPX and POTEE genes by omic analysis in breast cancer
Çine, Naci; Baykal, Ahmet Tarık; Sünnetçi, Deniz; Cantürk, Zafer; Serhatlı, Müge; Savlı, Hakan (Spandidos Publications, 2014)Breast cancer is the most common cancer among women and accounts for 23% of all female types of cancers. It is well recognized that breast cancer represents a heterogeneous group of tumors, and the molecular events involved ... -
mTor Is a signaling hub in cell survival: A mass-spectrometry-based proteomics investigation
Tang, Zhi; Baykal, Ahmet Tarık; Gao, Hui; Quezada, Hernan Concha; Zhang, Haiyan; Bereczki, Erika; Serhatlı, Müge; Baykal, Betül; Acıoğlu, Çiğdem; Wang, Shan; Ioja, Eniko; Ji, Xinying; Zhang, Yan; Guan, Zhizhong; Winblad, Bengt; Pei, Jin-Jing (American Chemical Society, 2014)mTor plays a central role in controlling protein homeostasis and cell survival. Recently, we have demonstrated that perturbations of mTor signaling are implicated in Alzheimer's disease (AD) and that mTor complex 1 (mTorC1) ... -
The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies
Durdağı, Serdar; Avşar, Timuçin; Orhan, Müge Didem; Serhatlı, Müge; Balcıoğlu, Bertan Koray; Öztürk, Hasan Ümit; Kayabölen, Alişan; Çetin, Yüksel; Aydınlık, Şeyma; Bağcı-Önder, Tuğba; Tekin, Şaban; Demirci, Hasan; Güzel, Mustafa; Akdemir, Atilla; Çalış, Şeyma; Oktay, Lalehan; Tolu, İlayda; Bütün, Yaşar Enes; Erdemoğlu, Ece; Olkan, Alpsu; Tokay, Nurettin; Işık, Şeyma; Özcan, Ayşenur; Acar, Elif; Büyükkılıç, Şehriban; Yumak, Yeşim (Cell Press, 2022)Small molecule inhibitors have previously been investigated in different studies as possible therapeutics in the treatment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In the current drug repurposing ... -
A preliminary proteomic evaluation of smooth muscle cells in thoracic aortic aneurysms
Açılan Ayhan, Ceyda; Baykal, Betül; Serhatlı, Müge; Kaçar, Ömer; Adıgüzel, Zelal; Taş, Serpil; Baysal, Kemal; Baykal, Ahmet Tarık (The Scientific and Technological Research Council of Turkey, 2014)Aortic aneurysm is characterized as localized degeneration of the aorta leading to advanced weakening and widening of the vessel. While the exact mechanisms have yet to be determined, current studies indicate that the ... -
Proteomic study of the microdissected aortic media in human thoracic aortic aneurysms
Serhatlı, Müge; Baysal, Kemal; Açılan, Ceyda; Tuncer, Eylem; Bekpınar, Seldağ; Baykal, Ahmet Tarık (American Chemical Society, 2014)Aortic aneurysm is a complex multifactorial disease, and its molecular mechanism is not understood. In thoracic aortic aneurysm (TAA), the expansion of the aortic wall is lead by extracellular matrix (ECM) degeneration in ...